The one thing that kept bothering me with Mac OSX was the mouse acceleration. Being used to the mouse acceleration in Microsoft Windows (which is none) and going into Mac OSX could be somewhat of a disturbance. Especially if you are working a lot in Illustrator and Photoshop, were you'll need precise movements when doing something.
Of course this is just a thing that takes some time getting used to or you could use a fix. I've been complaining about the Mighty Mouse for some time now and I soon realized when I was emulating Windows with VMware Fusion that the mouse was following along better.
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